Thursday, 15 February 2024

Attention deficit hyperactivity disorder (ADHD)

Attention deficit hyperactivity disorder (ADHD)

CAUSES

The exact cause of attention deficit hyperactivity disorder (ADHD) is not fully understood, although a combination of factors is thought to be responsible.

Genetics

ADHD tends to run in families and, in most cases, it's thought the genes you inherit from your parents are a significant factor in developing the condition.

Research shows that parents and siblings of someone with ADHD are more likely to have ADHD themselves.

However, the way ADHD is inherited is likely to be complex and is not thought to be related to a single genetic fault.

Brain function and structure

Research has identified a number of possible differences in the brains of people with ADHD from those without the condition, although the exact significance of these is not clear.

For example, studies involving brain scans have suggested that certain areas of the brain may be smaller in people with ADHD, whereas other areas may be larger.

Other studies have suggested that people with ADHD may have an imbalance in the level of neurotransmitters in the brain, or that these chemicals may not work properly.

Groups at risk

Certain people are also believed to be more at risk of ADHD, including people:

who were born prematurely (before the 37th week of pregnancy) or with a low birthweight

with epilepsy

with brain damage – which happened either in the womb or after a severe head injury later in life.

If your problems are recent and did not occur regularly in the past, you're not considered to have ADHD. This is because it's currently thought that ADHD cannot develop for the first time in adults.

Other possible treatments

There are other ways of treating ADHD that some people with the condition find helpful, such as cutting out certain foods and taking supplements. However, there's no strong evidence these work, and they should not be attempted without medical advice.

Diet

People with ADHD should eat a healthy, balanced diet. Do not cut out foods before seeking medical advice.

Some people may notice a link between types of food and worsening ADHD symptoms. If this is the case, keep a diary of what you eat and drink, and what behaviour follows. Discuss this with a GP, who may refer you to a dietitian (a healthcare professional who specialises in nutrition).

Supplements

Some studies have suggested that supplements of omega-3 and omega-6 fatty acids may be beneficial for people with ADHD, although the evidence supporting this is very limited.

It's advisable to talk to a GP before using any supplements, because some can react unpredictably with medicine or make it less effective.

You should also remember that some supplements should not be taken long term, as they can reach dangerous levels in your body.

Tips for parents

If you're the parent of a child with ADHD:

be sure your GP or specialist helps you understand the difference between ADHD and any other problems your child may have

think about who else needs to know about your child's ADHD, such as their school or nursery

find out the side effects of any medicine your child takes and what you need to look out for

getting to know people at local support groups can stop you feeling isolated and help you to cope

Exercise

Make sure your child gets lots of physical activity during the day. Walking, skipping and playing sport can help your child wear themselves out and improve their quality of sleep.

Make sure they're not doing anything too strenuous or exciting near to bedtime.

Read our physical activity guidelines for children and young people, which includes information on getting active, and how much activity you and your child should be doing.

Eating

Keep an eye on what your child eats. If your child is hyperactive after eating certain foods, which may contain additives or caffeine, keep a diary of these and discuss them with a GP.

Bedtime

Stick to a routine. Make sure your child goes to bed at the same time each night and gets up at the same time in the morning.

Avoid overstimulating activities in the hours before bedtime, such as computer games or watching TV.

Night time

Sleep problems and ADHD can be a vicious circle. ADHD can lead to sleep problems, which in turn can make symptoms worse.

Many children with ADHD will repeatedly get up after being put to bed and have interrupted sleep patterns. Trying a sleep-friendly routine can help your child and make bedtime less of a battleground.

Help at school

Children with ADHD often have problems with their behaviour at school, and the condition can negatively affect a child's academic progress.

Speak to your child's teachers or their school's special educational needs co-ordinator (SENCO) about any extra support your child may need.

Adults with ADHD

If you're an adult living with ADHD, you may find the following advice useful:

if you find it hard to stay organised, then make lists, keep diaries, stick up reminders and set aside some time to plan what you need to do

let off steam by exercising regularly

find ways to help you relax, such as listening to music or learning breathing exercises for stress

if you have a job, speak to your employer about your condition, and discuss anything they can do to help you work better

if you're at college or university, ask about what adjustments can be made to support you, such as extra time to complete exams and coursework

talk to a doctor about your suitability to drive, as you'll need to tell the Driver and Vehicle Licensing Agency (DVLA) if your ADHD affects your driving

contact or join a local or national support group – these organisations can put you in touch with other people in a similar situation, and can be a good source of support, information and advice

Source 

Sunday, 4 February 2024

CANCER : WHAT YOU MUST KNOW

What is cancer ?

Cancer is a disease which occurs when changes in a group of normal cells within the body lead to uncontrolled, abnormal growth forming a lump called a tumour; this is true of all cancers except leukaemia (cancer of the blood). If left untreated, tumours can grow and spread into the surrounding normal tissue, or to other parts of the body via the bloodstream and lymphatic systems, and can affect the digestive, nervous and circulatory systems or release hormones that may affect body function.

Cancer tumours can be divided into three groups: benign, malignant or precancerous.

1. Benign tumours are not cancerous and rarely threaten life. They tend to grow quite slowly, do not spread to other parts of the body and are usually made up of cells quite similar to normal or healthy cells. They will only cause a problem if they grow very large, becoming uncomfortable or press on other organs - for example a brain tumour inside the skull.

2. Malignant tumours are faster growing than benign tumours and have the ability to spread and destroy neighbouring tissue. Cells of malignant tumours can break off from the main (primary) tumour and spread to other parts of the body through a process known as metastasis. Upon invading healthy tissue at the new site they continue to divide and grow. These secondary sites are known as metastases and the condition is referred to as metastatic cancer.

3. Precancerous (or premalignant) describes the condition involving abnormal cells which may (or is likely to) develop into cancer.

Cancer staging

The classification of cancer by anatomical extent of the disease, i.e. stage, is essential to patient care, research and cancer control. The UICC TNM staging system is the common language adopted by oncology health professionals to communicate on the cancer extent for individual patients. Once the stage of cancer is known and understood, this is often a basis for deciding appropriate treatment and individual prognosis. It can also be used to inform and evaluate treatment guidelines, and constitutes vital information for policy-makers developing or implementing cancer control, prevention plans and research.  

The TNM classification focuses on the anatomical extent of the tumour and is determined by assessing the following categories:  

· T describes the size of the main (primary) tumour 

· N describes whether the cancer has spread to the nearby lymph nodes

· M describes whether the cancer has metastasised (spread from the primary tumour to another part of the body)

Managing and treating cancer 

Your treatment depends on the type of cancer, where your cancer is, how big it is, whether it has spread, and your general health. The general types of treatments include: surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and gene therapy. 

Surgery

If a cancer has not metastasised (spread), surgery can remove the entire cancer which may completely cure the disease. Often, this is effective in removing the prostate or a breast or testicle.

Radiotherapy

Radiation treatment or radiotherapy uses high-energy rays to reduce a tumour or destroy cancer cells as a stand-alone treatment and in some cases in combination with other cancer treatments.

Chemotherapy 

Chemotherapy uses chemicals to interfere with the way cells divide - damaging of DNA - so that cancer cells will destroy themselves. These treatments target any rapidly dividing cells (not necessarily just cancer cells), but normal cells usually can recover from any chemical-induced damage while cancer cells cannot. Chemotherapy is generally used to treat cancer that has spread or metastasised because the medicines travel throughout the entire body. It is a necessary treatment for some forms of leukaemia and lymphoma. 

Immunotherapy 

Immunotherapy uses the body's own immune system to fight the cancer tumour. Immunotherapy may treat the whole body by giving an agent that can shrink tumours.

Hormone therapy 

Several cancers have been linked to some types of hormones, including breast and prostate cancer. Hormone therapy works to change hormone production in the body so that cancer cells stop growing or are killed completely.

Gene therapy 

The goal of gene therapy is to replace damaged genes with ones that work to address a root cause of cancer: damage to DNA. Other gene-based therapies focus on further damaging cancer cell DNA to the point where the cell destroys themselves. However, gene therapy is new and has not yet resulted in any successful treatment 

Survivorship 

Survivorship focuses on health and the physical, psychological, social and economic issues affecting people after the end of the primary treatment for cancer, including people who have no disease after finishing treatment, people who continue to receive treatment to reduce the risk of the cancer coming back and people with well controlled disease and few symptoms, who receive treatment to manage cancer as a chronic disease. 

Survivorship care includes issues related to follow-up care, the management of late side-effects of treatment, the improvement of quality of life and psychological and emotional health. Survivorship care includes also future anticancer treatment where applicable. Family members, friends and caregivers should also be considered as part of the survivorship experience. 

Palliative care 

Palliative care runs throughout a patient’s journey from diagnosis to cure or end of life, and is designed to relieve symptoms and improve a cancer patient’s quality of life. It can be used to respond to troubling symptoms such as pain or sickness, and also to reduce or control the side effects of cancer treatments. In advanced cancer, palliative treatment might help someone to live longer and to live comfortably, even if they cannot be cured.

Key Cancer Facts

Cancer is the second-leading cause of death worldwide.

10 million people die from cancer every year.

More than 40% of cancer-related death could be preventable as they are linked to modifiable risk factors such as smoking, alcohol use, poor diet and physical inactivity.

Almost at least one third of all deaths related to cancer could be prevented through routine screening, and early detection and treatment.

70% of cancer deaths occur in low-to-middle income countries.

Millions of lives could be saved each year by implementing resource appropriate strategies for prevention, early detection and treatment.

The total annual economic cost of cancer is estimated at US$1.16 trillion.

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